BDBM693406 N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)pyrimidin-4-yl)pyridin-2- yl)oxy)-2,3,6-trifluorophenyl)-1-(2- fluorophenyl)methanesulfonamide::US12071425, Compound 324::US12071425, Compound 325::US12071425, Compound 326::US12071425, Compound 327

SMILES Fc1ccccc1CS(=O)(=O)Nc1c(F)cc(Oc2ncccc2-c2ccnc(NC3CNCC(C3)C3CC3)n2)c(F)c1F

InChI Key InChIKey=MJJTWNUFXPHOLB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 693406   

LigandPNGBDBM693406(N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)p...)
Affinity DataIC50: 0.400nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693406(N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)p...)
Affinity DataIC50: 22nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693406(N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)p...)
Affinity DataIC50: 0.610nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent

LigandPNGBDBM693406(N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)p...)
Affinity DataIC50: 0.260nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent