BDBM693399 1-phenyl-N-(2,3,6-trifluoro-4-((3-(2-((5- methoxypiperidin-3-yl)amino)pyrimidin- 4-yl)pyridin-2- yl)oxy)phenyl)methanesulfonamide::US12071425, Compound 317::US12071425, Compound 318::US12071425, Compound 319

SMILES COC1CNCC(C1)Nc1nccc(n1)-c1cccnc1Oc1cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c1F

InChI Key InChIKey=BOMCYRFRWPDJDL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 693399   

LigandPNGBDBM693399(US12071425, Compound 319 | 1-phenyl-N-(2,3,6-trifl...)
Affinity DataIC50: 140nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693399(US12071425, Compound 319 | 1-phenyl-N-(2,3,6-trifl...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent

LigandPNGBDBM693399(US12071425, Compound 319 | 1-phenyl-N-(2,3,6-trifl...)
Affinity DataIC50: 0.480nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent