BDBM693395 N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoropiperidin-3-yl)amino)pyrimidin-4- yl)pyridin-2-yl)oxy)-5-methylphenyl)-1- phenylethane-1-sulfonamide hydrochloride::US12071425, Compound 313::US12071425, Compound 314

SMILES CC(c1ccccc1)S(=O)(=O)Nc1cc(C)c(Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@@H](F)C3)n2)c(F)c1F

InChI Key InChIKey=KDCTVYIZVJRXTP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693395   

LigandPNGBDBM693395(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoropiperi...)
Affinity DataIC50: 1.20nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693395(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoropiperi...)
Affinity DataIC50: 0.240nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent