BDBM693388 N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexyl)amino)pyrimidin-4- yl)pyridin-2-yl)oxy)-2,3,6- trifluorophenyl)-1- phenylmethanesulfonamide::US12071425, Compound 306::US12071425, Compound 307::US12071425, Compound 308

SMILES CN(C)C1CCC(CC1F)Nc1nccc(n1)-c1cccnc1Oc1cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c1F

InChI Key InChIKey=DPNSHTKNFHFSJU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 693388   

LigandPNGBDBM693388(N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexy...)
Affinity DataIC50: 43nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693388(N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexy...)
Affinity DataIC50: 0.310nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent

LigandPNGBDBM693388(N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexy...)
Affinity DataIC50: 83nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent