BDBM693280 1-phenyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5-fluoro-5-methyl-3- piperidyl)amino)pyrimidin-4-yl)-2- pyridyl)oxy)phenyl)methanesulfonamide::US12071425, Compound 190

SMILES C[C@@]1(F)CNC[C@H](C1)Nc1nccc(n1)-c1cccnc1Oc1cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c1F

InChI Key InChIKey=QMBRTFKFUROCJI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 693280   

LigandPNGBDBM693280(1-phenyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5-...)
Affinity DataIC50: 4.70nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693280(1-phenyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5-...)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693280(1-phenyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5-...)
Affinity DataIC50: 7.40nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693280(1-phenyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5-...)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed