BDBM693248 (S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-ylamino)pyrimidin-4- yl)pyridin-2- yloxy)phenyl)(phenyl)methanesulfonamide::US12071425, Compound 158

SMILES Cc1cc(NS(=O)(=O)Cc2ccccc2)c(F)cc1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1

InChI Key InChIKey=IFKMTMVDPOQDQT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 693248   

LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 5.10nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent

LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed