BDBM693198 (S)-N-(2,3-difluoro-4-((3-(2-(piperidin-3- ylamino)pyrimidin-4-yl)pyridin-2- yl)oxy)phenyl)-1- phenylmethanesulfonamide::US12071425, Compound 108

SMILES Fc1c(F)c(Oc2ncccc2-c2ccnc(N[C@H]3CCCNC3)n2)ccc1NS(=O)(=O)Cc1ccccc1

InChI Key InChIKey=LQJPEVBILKJFKR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 693198   

LigandPNGBDBM693198((S)-N-(2,3-difluoro-4-((3-(2-(piperidin-3- ylamino...)
Affinity DataIC50: 3.40nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693198((S)-N-(2,3-difluoro-4-((3-(2-(piperidin-3- ylamino...)
Affinity DataIC50: 88nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693198((S)-N-(2,3-difluoro-4-((3-(2-(piperidin-3- ylamino...)
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693198((S)-N-(2,3-difluoro-4-((3-(2-(piperidin-3- ylamino...)
Affinity DataIC50: 0.980nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed