BDBM693147 US12071408, Example III-01

SMILES COc1cc2nccc(Oc3c(F)cc(NC(=O)NC4CC4)c(Cl)c3F)c2cc1C(N)=O

InChI Key InChIKey=OSZVHJYNXBUVAH-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 693147   

TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 3.70nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
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Date in BDB:
12/6/2024
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 0.600nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
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Date in BDB:
12/6/2024
Entry Details
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TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 1.10nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 14nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 11nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetFibroblast growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 22nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 17nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 2.5nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetPlatelet-derived growth factor receptor alpha(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 7.90nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetEpidermal growth factor receptor(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 53nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 96nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM693147(US12071408, Example III-01)
Affinity DataIC50: 68nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent