BDBM693142 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-((3-methylene-1-azabicyclo[3.2.0]heptan-5-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol::US20240270758, Example Z19

SMILES Oc1cc(-c2ncc3c(nc(OCC45CCN4CC(=C)C5)nc3c2F)N2C[C@@H]3CC[C@H](C2)N3)c2c(cccc2c1)C#C

InChI Key InChIKey=ZHIUEIFRFLXDJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693142   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693142(4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8...)
Affinity DataIC50: 46nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693142(4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8...)
Affinity DataIC50: 67.8nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent