BDBM693139 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-((7-ethyl-2,3-dihydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-8-fluoropyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol ::US20240270758, Example Z16

SMILES CCC1=CCN2CCCC12COc1nc(N2C[C@@H]3CC[C@H](C2)N3)c2cnc(c(F)c2n1)-c1cc(O)cc2cccc(C#C)c12

InChI Key InChIKey=PKGOEFKQKOWMSE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693139   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693139(4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2...)
Affinity DataIC50: 60.7nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693139(4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent