BDBM693137 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-((2-(propan-ylidene) tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol::US20240270758, Example Z14

SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]-[#7]2-[#6]-[#6]-[#6]C2([#6]-[#8]-c2nc(-[#7]-3-[#6]-[#6]-4-[#6]-[#6]-[#6](-[#6]-3)-[#7]-4)c3cnc(c(F)c3n2)-c2cc(-[#8])cc3cccc(C#C)c23)[#6]-1

InChI Key InChIKey=SEIZLRJOQHKFGX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693137   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693137(4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8...)
Affinity DataIC50: 39.6nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693137(4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8...)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent