BDBM693107 4-(4-((8-amino-3-azabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol::US20240270758, Example Z2

SMILES NC1C2CCC1CN(C2)c1nc(OCC23CCCN2CCC3)nc2c(F)c(ncc12)-c1cc(O)cc2cccc(C#C)c12

InChI Key InChIKey=QFMYYEKLCJGHEN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693107   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693107(4-(4-((8-amino-3-azabicyclo[3.2.1]octan-3-yl)-8-fl...)
Affinity DataIC50: 186nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693107(4-(4-((8-amino-3-azabicyclo[3.2.1]octan-3-yl)-8-fl...)
Affinity DataIC50: 788nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent