BDBM692500 US20240270735, Compound A124

SMILES FC(F)(F)Oc1ccc(NC(=O)Nc2ncc(s2)-c2ccncc2)cc1

InChI Key InChIKey=ODRXDIXPBYQYNN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 692500   

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692500(US20240270735, Compound A124)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 8(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692500(US20240270735, Compound A124)
Affinity DataIC50: 21nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692500(US20240270735, Compound A124)
Affinity DataIC50: 46nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 8(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692500(US20240270735, Compound A124)
Affinity DataIC50: 103nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent