BDBM690603 US12065430, Example 121

SMILES CC(C)(C)c1cc2c(NCc3nc(Cl)c(C(=O)NC4CN(C4)C(=O)C=C)n3[C@@H]3CCN(C3)C3COC3)n[nH]c2cc1Cl

InChI Key InChIKey=WUZSEOUXJUJFAB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 690603   

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM690603(US12065430, Example 121)
Affinity DataIC50: 5nMAssay Description:The inhibitory activity of compounds on exchange reaction of GDP into GppNHp in Bodipy (trademark) FL-bound KRAS G12C was examined by fluorescence me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent