BDBM690600 US12065430, Example 118

SMILES CN1CCCC(C1)n1c(CNc2n[nH]c3cc(Cl)c(cc23)C(C)(C)C)nc(Cl)c1C(=O)NC1CN(C1)C(=O)C=C

InChI Key InChIKey=MDWHSBYCGTYIRF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 690600   

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM690600(US12065430, Example 118)
Affinity DataIC50: 5nMAssay Description:The inhibitory activity of compounds on exchange reaction of GDP into GppNHp in Bodipy (trademark) FL-bound KRAS G12C was examined by fluorescence me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent