BDBM690546 US12065430, Example 64

SMILES Cc1nc(CNc2n[nH]c3cc(Cl)c(cc23)C(C)(C)C)n(C)c1C(=O)N[C@H]1CN(C[C@@H]1F)C(=O)C=C

InChI Key InChIKey=XCHLOIYRTYPUEH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 690546   

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM690546(US12065430, Example 64)
Affinity DataIC50: 13nMAssay Description:The inhibitory activity of compounds on exchange reaction of GDP into GppNHp in Bodipy (trademark) FL-bound KRAS G12C was examined by fluorescence me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent