BDBM690353 US20240262835, Compound 10

SMILES C[C@@H](N(Cc1ccc(cn1)C(F)(F)F)C(=O)c1cc2c(cn1)nc(N)c1cncn21)c1ncccn1

InChI Key InChIKey=ZQGUKMIPQXBQJZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 690353   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Antengene Discovery

US Patent
LigandPNGBDBM690353(US20240262835, Compound 10)
Affinity DataIC50: 54nMAssay Description:Table 1: The PRMT5 inhibitory activity of test compounds was determined using the MTase-Glo™ assay (Promega), which monitors the product (S-aden...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Antengene Discovery

US Patent
LigandPNGBDBM690353(US20240262835, Compound 10)
Affinity DataIC50: 379nMAssay Description:Table 2: The assay used recombinant full-length histone H2A as the substrate of PRMT5. Enzymatic transfer of the tritiated methyl group from S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
Go to US Patent