BDBM690344 US20240262835, Compound 1

SMILES Cn1ncc(c1-c1c(F)cc2ccccc2c1C#N)-c1ccc2c(c1)nc(N)c1cncn21

InChI Key InChIKey=LKBYJCDNXMFJJR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 690344   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Antengene Discovery

US Patent
LigandPNGBDBM690344(US20240262835, Compound 1)
Affinity DataIC50: 45nMAssay Description:Table 1: The PRMT5 inhibitory activity of test compounds was determined using the MTase-Glo™ assay (Promega), which monitors the product (S-aden...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Antengene Discovery

US Patent
LigandPNGBDBM690344(US20240262835, Compound 1)
Affinity DataIC50: 8nMAssay Description:Table 2: The assay used recombinant full-length histone H2A as the substrate of PRMT5. Enzymatic transfer of the tritiated methyl group from S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
Go to US Patent