BDBM689047 (S)-6-(6-Chloro-5-fluoro-2-oxo-1,2- dihydrospiro[benzo[d][1,3]oxazine- 4,3'-pyrrolidin]-1'-yl)-N-((6-((S)-3- fluoropyrrolidin-1-yl)pyridin-3- yl)methyl)pyridazine-4-carboxamide::US20240190892, Example 5

SMILES F[C@H]1CCN(C1)c1ccc(CNC(=O)c2cnnc(c2)N2CC[C@]3(C2)OC(=O)Nc2ccc(Cl)c(F)c32)cn1

InChI Key InChIKey=KFNLHPWUBHKESI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 689047   

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689047(US20240190892, Example 5 | (S)-6-(6-Chloro-5-fluor...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of plasma kallikrein can be determined using a relevant purified serine prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689047(US20240190892, Example 5 | (S)-6-(6-Chloro-5-fluor...)
Affinity DataIC50: 5.65E+3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent