BDBM688760 (7S,13R)-13-(difluoromethyl)-9-(2,6-difluorophenyl)-3,7-dimethyl-16-thia-2,4,5,8-tetrazatetracyclo [8.6.0.02,6.011,15]hexadeca-1(10),3,5,8,11(15)-pentaene::US20240190889, Example 5

SMILES C[C@@H]1N=C(c2c3C[C@H](Cc3sc2-n2c(C)nnc12)C(F)F)c1c(F)cccc1F

InChI Key InChIKey=ABTNVOCRBNFBHY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 688760   

LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  1.20nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
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LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  3.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  14.4nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  228nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent