BDBM688446 US20240190824, Compound 45::tert-butyl N-[4-chloro-3-[[3-methyl- 5-[2-(4-pyridyl)ethynyl]-2- pyridyl]carbamoyl]phenyl]carbamate

SMILES Cc1cc(cnc1NC(=O)c1cc(NC(=O)OC(C)(C)C)ccc1Cl)C#Cc1ccncc1

InChI Key InChIKey=LQSKVZMCSSOXNR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688446   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 688446BDBM688446(US20240190824, Compound 45 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 610nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688446BDBM688446(US20240190824, Compound 45 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 610nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed