BDBM688421 2-chloro-N-[3-methyl-5-(2- phenylethynyl)-2-pyridyl]-5- (tetrahydrofuran-4- ylmethoxy)benzamide::US20240190824, Compound 20

SMILES Cc1cc(cnc1NC(=O)c1cc(OCC2CCOCC2)ccc1Cl)C#Cc1ccccc1

InChI Key InChIKey=LWSWDKGFARTATM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688421   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688421(US20240190824, Compound 20 | 2-chloro-N-[3-methyl-...)
Affinity DataIC50: 90nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688421(US20240190824, Compound 20 | 2-chloro-N-[3-methyl-...)
Affinity DataIC50: 9nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent