BDBM688407 2-chloro-5-[(1- fluorocyclopropanecarbonyl)amino]- N-[3-fluoro-5-(2-phenylethynyl)-2- pyridyl]benzamide::US20240190824, Compound 6

SMILES Fc1cc(cnc1NC(=O)c1cc(NC(=O)C2(F)CC2)ccc1Cl)C#Cc1ccccc1

InChI Key InChIKey=BRHKELCBYHPVRM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688407   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688407(US20240190824, Compound 6 | 2-chloro-5-[(1- fluoro...)
Affinity DataIC50: 170nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688407(US20240190824, Compound 6 | 2-chloro-5-[(1- fluoro...)
Affinity DataIC50: 13nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent