BDBM688397 US20240190824, Compound 5::tert-butyl N-[4-chloro-3-[[5-[2-(3- fluorophenyl)ethynyl]-3-methyl-2- pyridyl]carbamoyl]phenyl]carbamate

SMILES Cc1cc(cnc1NC(=O)c1cc(NC(=O)OC(C)(C)C)ccc1Cl)C#Cc1cccc(F)c1

InChI Key InChIKey=YZOFBSQNPJCWMV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688397   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688397(US20240190824, Compound 5 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 210nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688397(US20240190824, Compound 5 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 13nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent