BDBM688396 2-chloro-N-[3-fluoro-5-[2-(3- fluorophenyl)ethynyl]-2-pyridyl]-5- [[(1S,2S)-2- methylcyclopropanecarbonyl]amino] benzamide::US20240190824, Compound 4

SMILES C[C@H]1C[C@@H]1C(=O)Nc1ccc(Cl)c(c1)C(=O)Nc1ncc(cc1F)C#Cc1cccc(F)c1

InChI Key InChIKey=WRIDEYYOAZBBKR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688396   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688396(US20240190824, Compound 4 | 2-chloro-N-[3-fluoro-5...)
Affinity DataIC50: 130nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688396(US20240190824, Compound 4 | 2-chloro-N-[3-fluoro-5...)
Affinity DataIC50: 8nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent