BDBM686257 US20240245694, Example 21C

SMILES C[C@H]1C[C@H](C(=O)Nc2ccc(cc2Cl)C(F)(F)F)n2c1c(N1CCN([C@H]3CC[C@H]13)C(=O)c1ncnc(C)c1O)c(=O)n1nc(nc21)C1=CCOCC1

InChI Key InChIKey=MLYLLFFMEGTICK-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 686257   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Human)
Novartis

US Patent

LigandBDBM686257(US20240245694, Example 21C)Copy SMILESCopy InChI

Affinity DataIC50: 40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/7/2024
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL