BDBM686225 (7R,9R) N-(2-chloro-6-(trifluoromethyl)pyridin-3-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-methyl-5-oxo-5,7,8,9-tetrahydropyrrolo[1,2-c][1,2,4]triazolo[1,5-a]pyrimidine-9-carboxamide::US20240245694, Example 4A

SMILES C[C@@H]1C[C@H](C(=O)Nc2ccc(nc2Cl)C(F)(F)F)n2c1c(N1CCN(CC1)C(=O)c1ncnc(C)c1O)c(=O)n1nc(nc21)N1CCOCC1

InChI Key InChIKey=MZBPIDIJJLSANH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 686225   

LigandPNGBDBM686225(US20240245694, Example 4A | (7R,9R) N-(2-chloro-6-...)
Affinity DataIC50: 90nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
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Date in BDB:
11/7/2024
Entry Details
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