BDBM686221 (7S,9R) N-(2-chloro-4-(trifluoromethyl)phenyl)-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-methyl-2-morpholino-5-oxo-5,7,8,9-tetrahydropyrrolo[1,2-c][1,2,4]triazolo[1,5-a]pyrimidine-9-carboxamide::US20240245694, Example 2C

SMILES C[C@H]1C[C@H](C(=O)Nc2ccc(cc2Cl)C(F)(F)F)n2c1c(N1CCN(CC1)C(=O)c1ncnc(C)c1O)c(=O)n1nc(nc21)N1CCOCC1

InChI Key InChIKey=NFEDBTCUSHIZJA-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 686221   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Human)
Novartis

US Patent

LigandBDBM686221(US20240245694, Example 2C | (7S,9R) N-(2-chloro-4-...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/7/2024
Entry Details
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