BDBM685835 (R,Z)-N-(1-(4-fluorophenyl)ethyl)-3-phenyl- N-(2-(pyrrolidin-1-yl)ethyl)-3-(4- (trifluoromethoxy)phenyl)prop-2-en-1- amine::US12043602, Compound PW361

SMILES C[C@@H](N(CCN1CCCC1)C\C=C(\c1ccccc1)c1ccc(OC(F)(F)F)cc1)c1ccc(F)cc1

InChI Key InChIKey=YHWWAMUTEKGUNO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685835   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685835(US12043602, Compound PW361 | (R,Z)-N-(1-(4-fluorop...)
Affinity DataIC50: 725nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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