BDBM685833 US12043602, Compound PW455

SMILES C[C@@H](N(CCN1CCCC1)C\C=C(\c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1

InChI Key InChIKey=CQVNHCNYZYKTMC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685833   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685833(US12043602, Compound PW455)
Affinity DataIC50: 1.86E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent