BDBM685832 US12043602, Compound PW454

SMILES COc1ccc(cc1)C(=C/CN(CCN1CCCC1)[C@H](C)c1ccc(F)cc1)\c1ccc(F)cc1

InChI Key InChIKey=SRYMGRQQSVZJDX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685832   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685832(US12043602, Compound PW454)
Affinity DataIC50: 319nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent