BDBM685819 (R)-N-(2-(1H-pyrrolo[2,3-b]pyridin-1- yl)ethyl)-N-(1-(4-fluorophenyl)ethyl)-3,3- diphenylprop-2-en-1-amine::US12043602, Compound PW297

SMILES [#6]-[#6@@H](-[#7](-[#6]-[#6]-n1ccc2cccnc12)-[#6]\[#6]=[#6](\c1ccccc1)-c1ccccc1)-c1ccc(F)cc1

InChI Key InChIKey=VPXGTXKAJKGTRK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685819   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685819(US12043602, Compound PW297 | (R)-N-(2-(1H-pyrrolo[...)
Affinity DataIC50: 2.27E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
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Date in BDB:
11/4/2024
Entry Details
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