BDBM685793 (R)-3-tert-butyl-1-(3,3-diphenylallyl)-1-(1- (4-methoxyphenyl)ethyl)urea::US12043602, Compound NY0428

SMILES [#6]-[#8]-c1ccc(cc1)-[#6@@H](-[#6])-[#7](-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1)-[#6](=O)-[#7]C([#6])([#6])[#6]

InChI Key InChIKey=NQFVHIHOCCXKBT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685793   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685793(US12043602, Compound NY0428 | (R)-3-tert-butyl-1-(...)
Affinity DataIC50: 290nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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