BDBM685774 (R)-N-(1-(4-methoxyphenyl)ethyl)-3,3- diphenyl-N-(2-(pyrrolidin-1- yl)ethyl)prop-2-en-1-amine::US12043602, Compound NY0331

SMILES [#6]-[#8]-c1ccc(cc1)-[#6@@H](-[#6])-[#7](-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-1)-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1

InChI Key InChIKey=AQVQGRVKHFDTIP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685774   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685774(US12043602, Compound NY0331 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 300nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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