BDBM685771 (R)-N-(1-(4-methoxyphenyl)ethyl)-N-(2- morpholinoethyl)-3,3-diphenylprop-2-en-1- amine::US12043602, Compound NY0316::US12043602, Compound NY0356::US12043602, Compound NY0358

SMILES [#6]-[#8]-c1ccc(cc1)-[#6@@H](-[#6])-[#7](-[#6]-[#6]-[#7])-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1

InChI Key InChIKey=MADXFRWJDPVTGY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 685771   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685771(US12043602, Compound NY0356 | US12043602, Compound...)
Affinity DataIC50: 4.40E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685771(US12043602, Compound NY0356 | US12043602, Compound...)
Affinity DataIC50: 4.19E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685771(US12043602, Compound NY0356 | US12043602, Compound...)
Affinity DataIC50: 1.15E+3nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent