BDBM685743 (S)-2-(bis(3,3-diphenylallyl)amino)-2-phenylethan-1-ol::US12043602, Compound AVA72::US20150344407, Compound 72

SMILES [#8]-[#6]-[#6@@H](-[#7](-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1)-[#6]\[#6]=[#6](\c1ccccc1)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=ZVZHCFIENQRGQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 685743   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685743(US12043602, Compound AVA72 | US20150344407, Compou...)
Affinity DataIC50: 170nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685743(US12043602, Compound AVA72 | US20150344407, Compou...)
Affinity DataIC50: 170nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent