BDBM6856 6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione::Indolocarbazole deriv. 4l

SMILES COc1ccc2c(c1)[nH]c1c3[nH]c4ccccc4c3c3C(=O)NC(=O)c3c21

InChI Key InChIKey=RPSCADUVKLRNEB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6856   

LigandPNGBDBM6856(6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 134nMpH: 7.0 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandPNGBDBM6856(6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 2.29E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandPNGBDBM6856(6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 236nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandPNGBDBM6856(6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM6856(6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 620nMAssay Description:Inhibition of N-terminal His10-StrepII tagged human ROCK2 catalytic domain (1 to 553 residues) expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed