BDBM685158 US20240239766, Example 38::US20240239766, Example 40

SMILES CN(C)[C@@]1(CCc2cccc(c2)C(F)(F)F)CCCN(C1)c1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=QSKUZQNYZKMNCW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 685158   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM685158(US20240239766, Example 40 | US20240239766, Example...)
Affinity DataIC50: 28.8nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM685158(US20240239766, Example 40 | US20240239766, Example...)
Affinity DataIC50: 531nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent