BDBM685141 (S)-4-(3-(Azetidin-1-yl)-3-(3-(trifluoromethyl)phenethyl)-piperidin-1-yl)-2-fluoro-N-(pyrimidin-4-yl)benzenesulfonamide, and (R)-4-(3-(azetidin-1-yl)-3-(3-(trifluoromethyl)phenethyl)piperidin-1-yl)-2-fluoro-N-(pyrimidin-4-yl)benzenesulfonamide::US20240239766, Example 21::US20240239766, Example 23

SMILES Fc1cc(ccc1S(=O)(=O)Nc1ccncn1)N1CCC[C@@](CCc2cccc(c2)C(F)(F)F)(C1)N1CCC1

InChI Key InChIKey=YTRTZUDRQMNRNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 685141   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM685141((S)-4-(3-(Azetidin-1-yl)-3-(3-(trifluoromethyl)phe...)
Affinity DataIC50: 3.18E+3nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM685141((S)-4-(3-(Azetidin-1-yl)-3-(3-(trifluoromethyl)phe...)
Affinity DataIC50: 8.60nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent