BDBM685127 (S)-4-(3-(Dimethylamino)-3-(4-(trifluoromethyl)-phenethyl)piperidin-1-yl)-2-fluoro-N-(pyrimidin-4-yl)benzenesulfonamide and (R)-4-(3-(Dimethylamino)-3-(4-(trifluoromethyl)phenethyl)piperidin-1-yl)-2-fluoro-N-(pyrimidin-4-yl)benzenesulfonamide::US20240239766, Example 7

SMILES CN(C)[C@@]1(CCc2ccc(cc2)C(F)(F)F)CCCN(C1)c1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=WBCMZYVRDCAPLB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685127   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM685127(US20240239766, Example 7 | (S)-4-(3-(Dimethylamino...)
Affinity DataIC50: 12.4nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent