BDBM684877 3-((1R)-1-(5-(3-amino-2,4-difluoro-6-(trifluoromethyl)phenyl)-4-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-8,9-dihydro-10H-7-oxa-1,3,6,10-tetraazacyclohepta[de]naphthalen-10-yl)ethyl)pyridin-2-amine::US20240228512, Example 621::US20260137699, Example 621
SMILES C[C@H](c1cccnc1N)N1CCOc2nc(-c3c(C(F)(F)F)cc(F)c(N)c3F)c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23
InChI Key InChIKey=UQYYMQRUYQZKFB-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 684877
Affinity DataIC50: 0.170nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Affinity DataIC50: 2.28nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Affinity DataIC50: 2.28nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair