BDBM684696 N-Cyclopropyl-1′-((7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)-1′,2′,3′,6′-tetrahydro-[3,4′-bipyridine]-6-carboxamide::US20240228490, Example 29::US20250034168, Compound 25

SMILES CCc1cc2ncc(CN3CCC(=CC3)c3ccc(nc3)C(=O)NC3CC3)cc2[nH]c1=O

InChI Key InChIKey=JTVAOZIMNFKWKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684696   

TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM684696(US20240228490, Example 29 | N-Cyclopropyl-1′...)
Affinity DataIC50: 0.980nMAssay Description:1. Experimental ObjectiveThe experimental objective of this Test Example is to determine the inhibitory activity of the compounds on PARP1 enzyme.2. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM684696(US20240228490, Example 29 | N-Cyclopropyl-1′...)
Affinity DataIC50: 0.360nMAssay Description:PARP-1 chemical fluorescence detection kit was purchased from BPS Bioscience. The histone solution in the kit was diluted 5× with 1×PBS, and 25 μL of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent