BDBM684560 US12030897, Example 4

SMILES Cc1cc(Nc2ncnn3ccc(CN4CCC(N)CC4)c23)ccc1Oc1ccn2ncnc2c1

InChI Key InChIKey=YRMOQCDUODUCRH-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 684560   

TargetCytochrome P450 1A2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 5.00E+4nMAssay Description:The object of this study was to evaluate the effect of Example 4 on the activities of five isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
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TargetCytochrome P450 2C9(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 5.00E+4nMAssay Description:The object of this study was to evaluate the effect of Example 4 on the activities of five isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 5.00E+4nMAssay Description:The object of this study was to evaluate the effect of Example 4 on the activities of five isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 3.61E+4nMAssay Description:The object of this study was to evaluate the effect of Example 4 on the activities of five isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 2.54E+4nMAssay Description:The object of this study was to evaluate the effect of Example 4 on the activities of five isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
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TargetCytochrome P450 3A4(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 3.24E+4nMAssay Description:The object of this study was to evaluate the effect of Example 4 on the activities of five isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 161nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 12nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684560(US12030897, Example 4)
Affinity DataIC50: 156nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent