BDBM683791 4-(2- {[(2R,7aS)-2- fluoro- hexahydro-1H- pyrrolizin-7a- yl]methoxy}-4- [(1S,6R)-3,9- diazabicyclo[4.2. 1]nonan-3-yl]- 8- fluoroquinazolin- 7-yl)-5- ethynyl-6- fluoronaphthalen- 2-ol::US20240217982, Example 11-6

SMILES Nc1cc(-c2ccc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c2c(C#C)c(F)ccc2c1

InChI Key InChIKey=MPOUCRUSNRGLHY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683791   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683791(US20240217982, Example 11-6 | 4-(2- {[(2R,7aS)-2- ...)
Affinity DataIC50: 20nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
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