BDBM683789 1-(2- {[(2R,7aS)-2- fluoro- hexahydro-1H- pyrrolizin-7a- yl]methoxy}-4- [(1S,6R)-3,9- diazabicyclo[4.2. 1]nonan-3-yl]- 8- fluoroquinazolin- 7-yl)-8- fluoroisoquinolin- 3-amine::US20240217982, Example 11-4

SMILES Nc1cc2cccc(F)c2c(n1)-c1ccc2c(nc(OC[C@@]34CCCN3C[C@H](F)C4)nc2c1F)N1CC[C@H]2CC[C@@H](C1)N2

InChI Key InChIKey=NVALHJZSEYDXPC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683789   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683789(US20240217982, Example 11-4 | 1-(2- {[(2R,7aS)-2- ...)
Affinity DataIC50: 2.20E+3nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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