BDBM683786 4-{4-[(1S,6R)-3,9-diazabicyclo[4.2.1]nonan-3-yl]-2-({1-[(dimethylamino)methyl]cyclopropyl}methoxy)-8-fluoroquinazolin-7-yl}-5-ethynyl-6-fluoronaphthalen-2-ol::US20240217982, Example 11-1

SMILES CN(C)CC1(COc2nc(N3CC[C@H]4CC[C@@H](C3)N4)c3ccc(c(F)c3n2)-c2cc(O)cc3ccc(F)c(C#C)c23)CC1

InChI Key InChIKey=SVSXOMVHOUPARG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683786   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683786(US20240217982, Example 11-1 | 4-{4-[(1S,6R)-3,9-di...)
Affinity DataIC50: 60nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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