BDBM683784 6-{6-chloro- 4-[(1S,6R)- 3,9- diazabicyclo [4.2.1]nonan- 3-yl]-8- fluoro-2- ({1-[(3- fluoropiperi- din-1- yl)methyl] cyclopropyl} methoxy) quinazolin-7- yl}-4- methyl-5- (trifluorometh- yl)pyridin- 2-amine::US20240217982, Example 10-10::US20240217982, Example 10-9

SMILES Cc1cc(N)nc(-c2c(Cl)cc3c(nc(OCC4(CN5CCCC(F)C5)CC4)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c1C(F)(F)F

InChI Key InChIKey=KWYFDWFXAMCRKB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 683784   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683784(US20240217982, Example 10-9 | US20240217982, Examp...)
Affinity DataIC50: 410nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683784(US20240217982, Example 10-9 | US20240217982, Examp...)
Affinity DataIC50: 20nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent