BDBM683780 6-(2- {[(2S,7aS)- 2- (difluorome- thoxy)- hexahydro- 1H- pyrrolizin- 7a- yl]methoxy}- 6-chloro-4- [(1S,6R)- 3,9- diazabicyclo [4.2.1]nonan- 3-yl]-8- fluoroquin- azolin-7-yl)-::US20240217982, Example 10-5::US20240217982, Example 10-6

SMILES Cc1cc(N)nc(-c2c(Cl)cc3c(nc(OC[C@@]45CCCN4C[C@H](C5)OC(F)F)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c1C(F)(F)F

InChI Key InChIKey=WPTOYIHLYLWOBO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 683780   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683780(US20240217982, Example 10-5 | US20240217982, Examp...)
Affinity DataIC50: 900nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683780(US20240217982, Example 10-5 | US20240217982, Examp...)
Affinity DataIC50: 200nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent