BDBM683779 6-{6-chloro- 4-[(1S,6R)- 3,9- diazabicyclo [4.2.1]nonan- 3-yl]-8- fluoro-2- [(1-{[(3R)- 3- fluoropyrrol- idin-1- yl]methyl} cyclopropyl) methoxy] quinazolin-7- yl}-4- methyl-5- (trifluorometh- yl)pyridin- 2-amine::US20240217982, Example 10-4

SMILES Cc1cc(N)nc(-c2c(Cl)cc3c(nc(OCC4(CN5CC[C@@H](F)C5)CC4)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c1C(F)(F)F

InChI Key InChIKey=COYRILNKKMVYRS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683779   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683779(US20240217982, Example 10-4 | 6-{6-chloro- 4-[(1S,...)
Affinity DataIC50: 110nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
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