BDBM683773 4-(2-{[(4aS,7aR)-1- methyl-octahydro-1H- cyclopenta[b]pyridin- 4a-yl]methoxy}-4- [(1S,6R)-3,9- diazabicyclo[4.2.1]nonan- 3-yl]-8- fluoroquinazolin-7-yl)- 5-fluoronaphthalen-2-ol::US20240217982, Example 9-2

SMILES CN1CCC[C@@]2(COc3nc(N4CC[C@H]5CC[C@@H](C4)N5)c4ccc(c(F)c4n3)-c3cc(O)cc4cccc(F)c34)CCC[C@@H]12

InChI Key InChIKey=GAESATBNVFCKII-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683773   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683773(US20240217982, Example 9-2 | 4-(2-{[(4aS,7aR)-1- m...)
Affinity DataIC50: 30nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
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